Subthalamic and thalamic local field potential recordings from patients with cervical dystonia

Wiest C
Torrecillos F
Morgante F
Pereira E
Tan H

This data set contains data that were used in Wiest et al., 2022.

The files are in MATLAB .mat format. The dataset is split into three .zip files.

Local field potentials (LFPs) were recorded from 7 patients with cervical dystonia (non-directional Boston Vercise leads with 8 contact levels, placed in the subthalamic nucleus, Zona incerta and ventrolateral thalamus). 5 patients were recorded bilaterally, yielding 12 hemispheres.

All channel labels are saved in SmrData.WvTits. LFPs were recorded from contact levels adjacent to the stimulation contact in bipolar fashion (label e.g. L13 if L2 was stimulated). All other LFPs were recorded in unipolar mode with common mode rejection (label e.g. L4). In addition, selected electroencephalography (EEG) contacts were recorded with common mode rejection (label e.g. C3). In some patients, electromyography (EMG, e.g. left splenius muscles (SplL) or left sternocleidomastoid muscle (SCML)) from dystonic neck muscles and accelerometer data (from the forehead or the vertex) were recorded. The time stamps and intensity of the applied stimulation currents are saved in channel Cur1/Am1.

In this dataset, we progressively increased stimulation intensity in steps of 0.5 mA until either the side effect threshold or 4.5 mA were reached. We tested all middle contacts (levels 2 to 7 if leads are labelled from 1 to 8) in this way.

In Participants 5 to 7, we applied single pulse stimulation (25 pulses) to all 8 contact levels in sequence (file name e.g. P6_Right_Single.mat).

Assistance with this dataset

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Diagram of a human torso with two deep brain electrodes, showing No-direction Boston Vercise leads in close-up
Year Published
Funders & Grant Numbers
Medical Research Council UK (MC_UU_00003/2, MR/P012272/1, MR/V00655X/1)
National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC)
Rosetrees Trust
University of Oxford
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