Nucleus accumbens core dopamine during Go-NoGo task

Syed EC
Grima LL
Magill PJ
Bogacz R
Brown P
Walton ME

Fast-scan cyclic voltammetry (FCV) data recorded in the nucleus accumbens core (NAcc) of rats carrying out a Go-NoGo task.

Channels recorded are either chan 0 - recorded in the right hemisphere or chan 1 - recorded in the left hemisphere. For study 1 (7 animals) there is only one channel recorded per animal in NAcc. For study 2 (6 animals) there is either one or two channels recorded in each animal. If there were two channels recorded these were recorded on separate dates.

Each FCV data file is named 'Stacked_Qcutoff'. Data provided here has undergone chemometric analysis and values are the recorded current (nA) corresponding to dopamine oxidation.  At each timepoint when the chemometric analysis failed to resolve dopamine from the recorded signal, the value is given as 'NaN'.

The data is a tab separated file, with continuous recordings organised in columns. The first column holds timestamps (resolution is 10 Hz) and all subsequent columns represent one trial.

Behavioural Data was recorded with MED-PC and is saved in text files found in the folder corresponding to the animal. 

For study 1 these will be named 'gonogo_rat(RatNumber)_(DateOfRecording)'. There is one behavioural file per animal.

For study 2 these will be named '009_(RatNumber)_step6v_(DateOfRecording). There are two behavioural files per animal.

For the trial types and event classes to interpret the behaviour data files, please read the text file in the zip archive.

Assistance with this dataset

We welcome researchers wishing to reuse our data to contact the creators of datasets. If you are unfamiliar with analysing the type of data we are sharing, have questions about the acquisition methodology, need additional help understanding a file format, or are interested in collaborating with us, please get in touch via email. Our current members have email addresses on our main site. The corresponding author of an associated publication, or the first or last creator of the dataset are likely to be able to assist, but in case of uncertainty on who to contact, email Ben Micklem, Research Support Manager at the MRC BNDU.

Dopamine (DA) signals in Nucleus Accumbens with and without movement. Top panel shows a behavioural trial where movement is initiated to collect reward. Bottom panel shows a trial where movement is withheld until after reward delivery.
Year Published
Funders & Grant Numbers
Wellcome Trust (WT090051MA)
Medical Research Council (MC_UU_12020/5)
Medical Research Council (MC_UU_12024/2)
Medical Research Council (MC_UU_12024/5)
Medical Research Council (MC_UU_12024/1)
University of Oxford
Downloaded times
First Published In
Syed EC, Grima LL, Magill PJ, Bogacz R, Brown P, Walton ME
2016.Nat. Neurosci., 19(1):34-6.

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