Bilateral tremor measurement in people with essential tremor under DBS-OFF and DBS-ON conditions

He S, Tan H, Cagnan H
Description

Task:

  1. Continuous DBS: Each participant was asked to maintain a tremor‐provoking posture such as raising both arms to shoulder level with flexed elbows and the fingers of both hands pointing to the center while sitting. The task was repeated in 6–8 blocks. Each block involved holding the tremor‐provoking posture for approximately 30 s, followed by 30‐s rest. The task was repeated in both DBS-OFF and DBS-ON conditions. Data were collected from in total 11 participants (raw data for 8 participants were shared).
  2. Phase-locked DBS: Similar tremor-provoking posture-holding task was performed by the participants. Phasic stimulation was delivered in blocks, with each block containing eight trials to track eight distinct tremor phases, resulting in a phase resolution of 45°. Each phasic stimulation trial represents tracking a specific tremor phase from one of the limbs for 7 s. Data were collected from two participants (raw data were not shared here due to ethical consideration). 

Data:  

  1. Raw data. Here raw data for each participant was stored in the corresponding folder named by participant ID (e.g., ‘cDBS_01’). In the folder, you will find two ‘.mat’ files for the raw data in DBS-OFF and DBS-ON conditions. The same data in the format of ‘.smr’ that can be visualised in Spike2 are also provided.
  2. Data structure. Each raw data file contains six variables, including ‘FileName’, sampling rate (‘SR’), channel names (‘WvTits’), data matrix (‘WvData’), markers (‘markerData’, values 2 and 3 indicate the start and end of each posture holding block), and marker timestamps (‘markerTime’, timestamps for the corresponding marker values in ‘markerData’). 

  3. Processed data. There are three processed ‘.mat’ files, including: 

    ‘myTable_2025_06_13.mat’ contains trial-by-trial results, that can be used to generate the figures and tables in the published paper (He et al., 2025, Movement Disorders).

    ‘phasicResultSigAvgPhase_2023_02_08_01.mat’ contains phasic-DBS results (with statistics) for participant ‘phasicDBS_01’.

    ‘phasicResultSigAvgPhase_2023_02_08_02.mat’ contains phasic-DBS results (with statistics) for participant ‘phasicDBS_02’.

  4. Source Matlab Code.  Three ‘.m’ files for Matlab code. With the provided raw and/or processed data, results in all figures and tables of the paper should be able to reproduce.
Assistance with this dataset

We welcome researchers wishing to reuse our data to contact the creators of datasets. If you are unfamiliar with analysing the type of data we are sharing, have questions about the acquisition methodology, need additional help understanding a file format, or are interested in collaborating with us, please get in touch via email. Our current members have email addresses on our main site. The corresponding author of an associated publication, or the first or last creator of the dataset are likely to be able to assist, but in case of uncertainty on who to contact, email Ben Micklem, Research Support Manager at the MRC BNDU.

Bilateral tremor signals while performing posture holding task were measured using accelerometer sensors, in both DBS-OFF and DBS-ON states.
Year Published
2025
DOI
10.60964/bndu-1tv5-4967
Metadata
DataCite XML
Funders
Medical Research Council (MC_UU_00003/2, MR/R020418/1, MR/X023141/1)
National Institute for Health Research Oxford Biomedical Research Centre
Guarantors of Brain
Publisher
University of Oxford
Downloaded times
First Published In
He S, Deli A, West TO, Plazas FR, Pogosyan A, Wiest C, Wehmeyer L, Baig F, Morgante F, Andrade P, Hart MG, Fitzgerald J, Visser-Vandewalle V, Pereira EA, Green AL, Tan H, Cagnan H
Tremor Asymmetry and the Development of Bilateral Phase-Specific Deep Brain Stimulation for Postural Tremor.
2025. Mov Disord (e-Pub ahead of print).
Free Full Text PDF here
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